Through the first decades of the 21st century, the Berlin-Brandenburg region has become an important production location, first for international films and then, most recently, also for transnational television drama series. Since 2015, more than 20 transnational TV drama series were produced in the region. Berlin has been attracting talent from all over the world, becoming a hotspot for international production where both above and below-the line talents from different countries work together in a creative and productive way. In this article, I argue that Berlin has thus successfully established a cosmopolitan production culture. In what follows, I outline the cosmopolitan conditions that underpin Berlin’s production culture and the creative collaboration of talent with different cultural backgrounds.